Indiana vs. Nebraska Prediction, Odds, Picks for College Football Week 6

The safeguarding nationwide champs satisfy 5-0 Nebraska in this week’s Big Noon Kickoff video game. No. 7 Indiana and the Cornhuskers square off in Week 6 of college football on FOX.

Matt Rhule has Nebraska off to its finest start given that 2016, when the Cornhuskers opened 7-0. They’ve scored a minimum of 30 points in every video game this season for the very first time because 2014.

The Cornhuskers are perhaps among the greatest surprises of the season, and now they have a possibility to put the entire nation on notification. A chance at knocking off the protecting champs is the type of chance a group imagine.

Curt Cignetti and Indiana have not avoided a beat because last season. The Hoosiers once again boast among the country’s leading defenses and an offense that looks after the ball. They’ve won 21 straight video games and have not lost a regular-season roadway video game because falling at Ohio State in November 2024.

Let’s have a look at the chances for No. 7 Indiana vs. Nebraska at FanDuel Sportsbook since Oct. 10.

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Moneyline

• Indiana: -305 (wager $10 to win $13.28 overall)
• Nebraska: +245 (wager $10 to win $34.50 overall)

Spread

• Indiana -7.5: -105 (wager $10 to win $19.52 overall)
• Nebraska +7.5: -115 (wager $10 to win $18.70 overall)

Over/Under

• Over 48.5: -112 (wager $10 to win $18.93 overall)
• Under 48.5: -108 (wager $10 to win $19.26 overall)

From FOX Sports Research:

Just 3 Big Ten groups typical a minimum of 40 points per video game while permitting 14 or less, and 2 of them satisfy in this match.

Nebraska faced its very first genuine difficulty of the season recently versus Maryland, falling back 23-14– its biggest deficit of the year. The Cornhuskers reacted with 34 unanswered points and travelled to a 48-23 win. Quarterback Anthony Colandrea tossed for 238 backyards and 3 goals, including 108 backyards on the ground.

Like Nebraska, Indiana has actually rolled previous almost every challenger, however one group provided the Hoosiers an unforeseen scare. Northwestern had Indiana on the ropes late in the 4th quarter and was one onside kick healing far from a possibility at an upset. Curt Cignetti and the Hoosiers hung on, then throttled Rutgers 47-15 on the roadway.

These groups share another characteristic: they secure the ball. Indiana has actually devoted simply one turnover all season, a fumble by running back Lee Beebe Jr., while quarterback Josh Hoover has yet to toss an interception. Nebraska has actually devoted simply 2 turnovers, both Colandrea interceptions.

Both groups are stingy on defense, however with offenses like these, points can come rapidly and in lots. Anticipate lots of them in this week’s Big Noon Kickoff match.

How to Watch No. 7 Indiana vs. Nebraska

• Date: Saturday, Oct. 10, 2026
• Time: 12 p.m. ET
• TELEVISION: FOX
• Stream: Enjoy 3 days totally free on FOX One FOXSports.comFOX Sports App
• Area: Memorial Stadium, Lincoln, Nebraska

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