Recordanelles capture transient gene expression in single human cells

RNA sequencing can catch high-resolution photos of a cell’s transcriptome, however short-term modifications in private cells can not be caught over extended periods at a transcriptome-wide scale. Now, an artificial organelle called the ‘recordanelle’ can tape cellular RNAs in cells for a number of days and read with single-cell level of sensitivity. This is a sneak peek of membership material, gain access to through your organization 19659003 Gain access to alternatives 19459212 Gain access to through your organization 19659004 19659005 Gain access to Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access membership $32.99 / 30 days cancel at any time 19659009 Find out more 19659010 Register for this journal Get 12 print concerns and online gain access to $259.00 19459212 each year 19659013 just $21.58 per concern 19659014 Find out more Purchase this short article 19659016 Purchase on SpringerLink 19659017 Instantaneous access to the complete short article PDF. USD 39.95 19659019 Rates might undergo regional taxes which are determined throughout checkout 19659020 19659021 Fig. 1: Recordanelles record short-term transcription occasions. 19659022 19659023 Topics References 19459209 Askary, A. et al. The lives of cells, tape-recorded. 19459243 Nat. Rev. Genet. 19659025 26 19459226, 203– 222(2025). This evaluation talks about DNA-based recording innovations. Article CAS PubMed Google Scholar 19459207 Schmidt, F., Cherepkova, M. Y. & Platt, R. J. Transcriptional recording by CRISPR spacer acquisition from RNA. 19459243 Nature 19659028 562 , 380– 385(2018). This paper developed CRISPR-based RNA recording in prokaryotic cells. 19659029 Article CAS PubMed data-track-value=19459056 data-track-label=19459006 data-track-item_id=rel=aria-label=href=http://> Google Scholar 19459207 Choi, J. et al. A time-resolved, multi-symbol molecular recorder through consecutive genome modifying. 19459243 Nature 608 19459226, 98– 107(2022). 19459245 This paper developed prime-editing-based DNA typewriting. 19659032 Article CAS PubMed Central Google Scholar 19459207 19659033 Najia, M. A. et al. Live-cell transcriptomics with crafted virus-like particles. Cell https://doi.org/10.1016/j.cell.2026.08.005 19459207 (2026 ). 19459245 This work established an innovation that makes it possible for the export of RNAs from cells into the medium for transcriptomics. 19659034 Chao, Y.-K., Wu, M., Gong, Q. & Chen, F. A genetically encoded gadget for transcriptome storage in mammalian cells. Science 19659035 391 , eadz9353 (2026). 19459245 This work established an RNA recording innovation based upon vault particles. 19659036 Article CAS PubMed Google Scholar 19459207 19659037 Download recommendations 19659038