Tennis
Data schedule 19460504 19460505 The RBD series utilized for this research study is offered at GenBank(OP839194 19460507 19460508 43 19460509 Datasets created and examined throughout these research studies are readily available at a public Zenodo repository (https://zenodo.org/records/21726997 19460507 19460508 41 19460509 Extra datasets are readily available from the matching author upon affordable demand.
Code accessibility Bayesian optimization explained in this work is executed within the AutODEx structure offered at https://autodex.ai 19460507 (refs. 37,38. Extra application information can be discovered at https://autodex.csail.mit.edu 19460507 The source code can be discovered at https://github.com/yunshengtian/AutoOED (ref. 57 19460509. 19460512
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Download referrals 19460507 19460512 Acknowledgements We thank the Koch Institute’s Robert A. Swanson( 1969 )Biotechnology Center for technical assistance, particularly the Peterson (1957)Nanotechnology for Integrative BioEM Core Facility (RRID: SCR_018674), the Nanotechnology Materials core, the BioMicroCenter and the Animal Imaging and Preclinical Testing centers. We thank N. Chaudhary for his assistance on tissue harvesting and circulation cytometry. We thank P. Konaković and Y. Tian for their aid with algorithm execution and usage of AutODEx. Funding 19460504 J.T. is a recipient of the MIT-Takeda Fellowship Award and the Siebel Scholar Award. K.T.M.T. gets postdoctoral fellowship assistance from the Ludwig Center at MIT ‘s Koch Institute for Integrative Cancer Research, the Convergence Scholars Program at MIT Marble Center for Cancer Nanomedicine and the International Pharmaceutical Excipients Council Foundation Emerging Research Award Funding. This work was supported, in part, by the Koch Institute Support(core) Grant P30-CA14051 from the National Cancer Institute. This work was supported, in entire or& in part, by the Gates Foundation (INV-061250). The conclusions and viewpoints revealed in this work are those of the author (s)alone and will not be credited to the Gates Foundation.
Under the grant conditions of the Gates Foundation, a Creative Commons Attribution 4.0 License has actually currently been designated to the Author Accepted Manuscript variation that may develop from this submission. Please note that works sent as a preprint have actually not gone through a peer evaluation procedure. Author info 19460505 Author notes These authors contributed similarly: Jinbi Tian, Khanh T. M. Tran. Authors and Affiliations 19460812 19460809 19460505 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Jinbi Tian, Khanh T. M. Tran, Brett H. Pogostin, Olivia Sheridan, Sevinj Mursalova, Amy H. Lee, Shuai Liu, Jaya Hamkins, Zane S. Dash, Dongsoo Yun, Robert S. Langer & Ana Jaklenec 19460532 Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Jinbi Tian & Mina Konaković Luković
19460511 19460532 19460505 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Daniel Antov 19460511 19460505 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Alana L. Power 19460532 19460505 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Robert S. Langer 19460511 19460532 19460798 19460505 Authors 19460819 Jinbi Tian 19460808 19460532 19460819 Khanh T. M. Tran Brett H. Pogostin 19460532 Olivia Sheridan 19460532 19460819 Sevinj Mursalova Amy H. Lee 19460808 19460532 Shuai Liu 19460808 19460532 Jaya Hamkins Daniel Antov Alana L. Power 19460808 19460819 Zane S. Dash 19460808 19460532 Dongsoo Yun 19460808 19460532 19460819 Mina Konaković Luković 19460532 Robert S. Langer 19460808 19460532 19460819 Ana Jaklenec 19460808 19460532
19460798 Contributions J.T. and K.T.M.T. developed the research study, developed and carried out the experiments, examined the information and composed the manuscript. B.H.P., O.S., S.M., A.H.L., S.L., J.H., D.A., A.L.P., D.Y. and Z.S.D. added to experiments, information collection and information analysis. M.K.L. supplied assistance on the algorithm advancement, application and information analysis. R.S.L. and A.J. developed and monitored the research study, protected financing, analyzed the information and modified the manuscript. All authors went over the outcomes, supplied crucial feedback and authorized the last manuscript. Corresponding authors 19460812 Correspondence to Robert S. Langer or Ana Jaklenec. 19460512
Ethics statements 19460504 Completing interests 19460812 From Fiscal Year 2020 to today, A.J. gets licensing charges (for patents on which she was an innovator)from, has financial investments in, consults( or was on Scientific Advisory Boards or Boards of Directors )for, lectured (and got a cost) or performs sponsored research study at MIT for which she was not spent for the following entities: The Estée Lauder Companies, Moderna Therapeutics, OmniPulse Biosciences, Particles for Humanity, SiO2 Materials Science and VitaKey. From Fiscal Year 2020 to today, R.S.L. gets licensing costs(for patents on which he was a creator)from, has financial investments in, consults(or was on Scientific Advisory Boards or Boards of Directors)for, lectured(and got a cost)or carries out sponsored research study at MIT for which he was not spent for the following entities: https://www.dropbox.com/scl/fo/9hrpxuzs72iwvmoqze7rx/AA_OoThWVjAex7X_LhwLRcw?rlkey=llza5qcutubtyx34uqrrfy141&st=zcgqc4qp&dl The staying authors state no completing interests. 19460511 19460512 Peer evaluation 19460504 Peer evaluation details 19460812 Nature Biotechnology thanks Yujia Cai, Yizhou Dong and the other, confidential, customer(s)for their contribution to the peer evaluation of this work. 19460511
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Supplementary info Rights and authorizations 19460504 19460505 Springer Nature or its licensor(e.g. a society or other partner)holds special rights to this short article under a publishing arrangement with the author(s)or other rightsholder(s); author self-archiving of the accepted manuscript variation of this post is exclusively governed by the regards to such publishing contract and appropriate law. 19460505 Reprints and approvals 19460507 19460511 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
References 19460504 Baden, L. R. et al. Effectiveness and security of the mRNA-1273 SARS-CoV-2 vaccine. N. Engl. J. Med. 19460527 384 , 403– 416(2021).
19460511 19460505 Article CAS PubMed 19460507 Google Scholar 19460507 19460511 19460532 Polack, F. P. et al. Security and effectiveness of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383 ., 2603– 2615(2020). 19460511 19460505 Article
19460507 CAS PubMed Central 19460507 Google Scholar 19460507 19460532 Huang, X. et al. The landscape of mRNA nanomedicine. Nat. Medication. 28 , 2273– 2287(2022).
19460511 19460505 Article 19460507
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Jiang, A. Y. et al. Combinatorial advancement of nebulized mRNA shipment formulas for the lungs. Nat. Nanotechnol. 19460526 19 19460528, 364– 375( 2024). 19460511 19459905 data-track-value=19459027 data-track-action=href=19459909 aria-label=data-doi=19459905> Article 19460507 CAS PubMed 19460507 Google Scholar 19460507 19460511 Doan, T. N. K., Davis, M. M. & Croyle, M. A. Identification of film-based solutions that move mRNA lipid nanoparticles out of the freezer. Mol. Ther. Nucleic Acids 35 19460528, 102179 (2024).. 19460532 Reker, D. et al. ‘Inactive’ components in oral medications. Sci. Transl. Medication. 19460526 11 , eaau6753 (2019). 19460511 Article 19460507 PubMed 19460507 PubMed Central Google Scholar 19460511 19460532 Ionova, Y. & Wilson, L. Biologic excipients: value of medical awareness of non-active components. 19460525 PLoS ONE 19460526 15 , e0235076 (2020). 19460511 Article CAS PubMed PubMed Central 19460507 Google Scholar 19460507 19460532 Shahriari, B., Swersky, K., Wang, Z., Adams, R. P. & De Freitas, N. Taking the human out of the loop: an evaluation of Bayesian optimization. Proc. IEEE 104 , 148– 175 (2015). 19460505 Article 19460507 Google Scholar 19460507 19460511 Tian, Y. et al. AutODEx: automated ideal style of experiments platform with data-and time-efficient multi-objective optimization. In NeurIPS 2023 Workshop on Adaptive Experimental Design and Active Learning in the Real World 19460526 https://openreview.net/forum?id=YrAXARes9d (2023). 19460511 Tian, Y. et al. AutODEx: automated optimum style of experiments platform with information – and time-efficient multi-objective optimization. https://autodex.csail.mit.edu/ 19460507 (2023). 19460532 Zhang, L. et al. Result of mRNA-LNP parts of 2 globally-marketed COVID-19 vaccines on effectiveness and stability. 19460525 NPJ Vaccines 8 19460528, 156 (2023). 19460505 Article CAS PubMed 19460507 PubMed Central 19460507 Google Scholar 19460532 Zhan, D. & Xing, H. Expected enhancement for costly optimization: an evaluation. 19460525 J. Glob. Optim. 19460527 78 , 507– 544 (2020). 19460511 19460505 Article Google Scholar 19460532 Tian, J. Datasets for sped up discovery of thermostable vaccines utilizing data-efficient AI. 19460525 Zenodo https://doi.org/10.5281/zenodo.21726997 19460507 (2026). 19460532 Cheng, M. H. Y. et al. Induction of bleb structures in lipid nanoparticle solutions of mRNA results in enhanced transfection strength. 19460525 Adv. Mater. 19460527 35 , 2303370 (2023). 19460505 Article 19460507 CAS Google Scholar 19460532 Daristotle, J., Vander Straeten, A., Langer, R. & Jaklenec, A. Synthetic construct SARS-CoV-2 vaccine receptor binding domain gene. GenBank https://www.ncbi.nlm.nih.gov/nuccore/OP839194 (2023). 19460511 19460532 Sharma, A., Khamar, D., Cullen, S., Hayden, A. & Hughes, H. Innovative drying innovations for biopharmaceuticals. 19460525 Int. J. Pharm. 609 , 121115 (2021). 19460505 Article CAS PubMed Google Scholar 19460511 Lutzmayer, S., Osoianu, E. &, Rosenfeld, T. Tip of the iceberg: financial and ecological effect of the vaccine cold chain. https://www.iqvia.com/locations/emea/library/white-papers/tip-of-the-iceberg-economic-and-environmental-impact-of-the-vaccine-cold-chain 19460507 (2025). Wahl, C. B. et al. Artificial intelligence– sped up style and synthesis of polyelemental heterostructures. 19460525 Sci. Adv. 19460526 7 19460528, eabj5505 (2024). 19460511 Article Google Scholar 19460507 Erps, T. et al. Sped up discovery of 3D printing products utilizing data-driven multiobjective optimization. 19460525 Sci. Adv. 19460526 7 , eabf7435 (2021). 19460511 Article CAS PubMed 19460507 PubMed Central 19460507 Google Scholar 19460507 19460511 19460532 Sedic, M. et al. Security examination of lipid nanoparticle– developed customized mRNA in the Sprague-Dawley rat and cynomolgus monkey. 19460525 Veterinarian. Pathol. 55 , 341– 354 (2018). Article 19460507 CAS PubMed Google Scholar 19460532 Lv, H., Zhang, S., Wang, B., Cui, S. & Yan, J. Toxicity of cationic lipids and cationic polymers in gene shipment. J. Control. Release 19460527 114 , 100– 109 (2006). Article 19460507 CAS PubMed Google Scholar 19460507 19460532 Kedmi, R., Ben-Arie, N. & Peer, D. The systemic toxicity of favorably charged lipid nanoparticles and the function of Toll-like receptor 4 in immune activation. Biomaterials 31 , 6867– 6875 (2010). 19460511 Article 19460507 CAS PubMed Google Scholar 19460507
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Google Scholar 19460507 19460511 Simonsen, J. B. A point of view on bleb and empty LNP structures. J. Control. Release 19460526 373 19460528
, 952– 961(2024). 19460511 Article CASdata-track-action=href=aria-label=> PubMed 19460507 Google Scholar 19460511 Garnett, R. Modeling with Gaussian procedures. In 19460525 Bayesian Optimization 19460526(ed. Garnett, R. )45 − 66 https://doi.org/10.1017/9781108348973.004 (Cambridge Univ. Press, 2023). Garnett, R. Common Bayesian optimization policies. In 19460525 Bayesian Optimization 19460526(ed. Garnett, R. )123 − 156 https://doi.org/10.1017/9781108348973.008 (Cambridge Univ. Press, 2023 ). 19460511 19460532 Tian, Y. AutoOED: automated optimum speculative style platform. https://github.com/yunshengtian/AutoOED.git (2021). 19460798
Download referrals 19460507 19460512 Acknowledgements We thank the Koch Institute’s Robert A. Swanson( 1969 )Biotechnology Center for technical assistance, particularly the Peterson (1957)Nanotechnology for Integrative BioEM Core Facility (RRID: SCR_018674), the Nanotechnology Materials core, the BioMicroCenter and the Animal Imaging and Preclinical Testing centers. We thank N. Chaudhary for his assistance on tissue harvesting and circulation cytometry. We thank P. Konaković and Y. Tian for their aid with algorithm execution and usage of AutODEx. Funding 19460504 J.T. is a recipient of the MIT-Takeda Fellowship Award and the Siebel Scholar Award. K.T.M.T. gets postdoctoral fellowship assistance from the Ludwig Center at MIT ‘s Koch Institute for Integrative Cancer Research, the Convergence Scholars Program at MIT Marble Center for Cancer Nanomedicine and the International Pharmaceutical Excipients Council Foundation Emerging Research Award Funding. This work was supported, in part, by the Koch Institute Support(core) Grant P30-CA14051 from the National Cancer Institute. This work was supported, in entire or& in part, by the Gates Foundation (INV-061250). The conclusions and viewpoints revealed in this work are those of the author (s)alone and will not be credited to the Gates Foundation.
Under the grant conditions of the Gates Foundation, a Creative Commons Attribution 4.0 License has actually currently been designated to the Author Accepted Manuscript variation that may develop from this submission. Please note that works sent as a preprint have actually not gone through a peer evaluation procedure. Author info 19460505 Author notes These authors contributed similarly: Jinbi Tian, Khanh T. M. Tran. Authors and Affiliations 19460812 19460809 19460505 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Jinbi Tian, Khanh T. M. Tran, Brett H. Pogostin, Olivia Sheridan, Sevinj Mursalova, Amy H. Lee, Shuai Liu, Jaya Hamkins, Zane S. Dash, Dongsoo Yun, Robert S. Langer & Ana Jaklenec 19460532 Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Jinbi Tian & Mina Konaković Luković
19460511 19460532 19460505 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Daniel Antov 19460511 19460505 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Alana L. Power 19460532 19460505 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Robert S. Langer 19460511 19460532 19460798 19460505 Authors 19460819 Jinbi Tian 19460808 19460532 19460819 Khanh T. M. Tran Brett H. Pogostin 19460532 Olivia Sheridan 19460532 19460819 Sevinj Mursalova Amy H. Lee 19460808 19460532 Shuai Liu 19460808 19460532 Jaya Hamkins Daniel Antov Alana L. Power 19460808 19460819 Zane S. Dash 19460808 19460532 Dongsoo Yun 19460808 19460532 19460819 Mina Konaković Luković 19460532 Robert S. Langer 19460808 19460532 19460819 Ana Jaklenec 19460808 19460532
19460798 Contributions J.T. and K.T.M.T. developed the research study, developed and carried out the experiments, examined the information and composed the manuscript. B.H.P., O.S., S.M., A.H.L., S.L., J.H., D.A., A.L.P., D.Y. and Z.S.D. added to experiments, information collection and information analysis. M.K.L. supplied assistance on the algorithm advancement, application and information analysis. R.S.L. and A.J. developed and monitored the research study, protected financing, analyzed the information and modified the manuscript. All authors went over the outcomes, supplied crucial feedback and authorized the last manuscript. Corresponding authors 19460812 Correspondence to Robert S. Langer or Ana Jaklenec. 19460512
Ethics statements 19460504 Completing interests 19460812 From Fiscal Year 2020 to today, A.J. gets licensing charges (for patents on which she was an innovator)from, has financial investments in, consults( or was on Scientific Advisory Boards or Boards of Directors )for, lectured (and got a cost) or performs sponsored research study at MIT for which she was not spent for the following entities: The Estée Lauder Companies, Moderna Therapeutics, OmniPulse Biosciences, Particles for Humanity, SiO2 Materials Science and VitaKey. From Fiscal Year 2020 to today, R.S.L. gets licensing costs(for patents on which he was a creator)from, has financial investments in, consults(or was on Scientific Advisory Boards or Boards of Directors)for, lectured(and got a cost)or carries out sponsored research study at MIT for which he was not spent for the following entities: https://www.dropbox.com/scl/fo/9hrpxuzs72iwvmoqze7rx/AA_OoThWVjAex7X_LhwLRcw?rlkey=llza5qcutubtyx34uqrrfy141&st=zcgqc4qp&dl The staying authors state no completing interests. 19460511 19460512 Peer evaluation 19460504 Peer evaluation details 19460812 Nature Biotechnology thanks Yujia Cai, Yizhou Dong and the other, confidential, customer(s)for their contribution to the peer evaluation of this work. 19460511
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Supplementary info Rights and authorizations 19460504 19460505 Springer Nature or its licensor(e.g. a society or other partner)holds special rights to this short article under a publishing arrangement with the author(s)or other rightsholder(s); author self-archiving of the accepted manuscript variation of this post is exclusively governed by the regards to such publishing contract and appropriate law. 19460505 Reprints and approvals 19460507 19460511 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
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Download referrals 19460507 19460512 Acknowledgements We thank the Koch Institute’s Robert A. Swanson( 1969 )Biotechnology Center for technical assistance, particularly the Peterson (1957)Nanotechnology for Integrative BioEM Core Facility (RRID: SCR_018674), the Nanotechnology Materials core, the BioMicroCenter and the Animal Imaging and Preclinical Testing centers. We thank N. Chaudhary for his assistance on tissue harvesting and circulation cytometry. We thank P. Konaković and Y. Tian for their aid with algorithm execution and usage of AutODEx. Funding 19460504 J.T. is a recipient of the MIT-Takeda Fellowship Award and the Siebel Scholar Award. K.T.M.T. gets postdoctoral fellowship assistance from the Ludwig Center at MIT ‘s Koch Institute for Integrative Cancer Research, the Convergence Scholars Program at MIT Marble Center for Cancer Nanomedicine and the International Pharmaceutical Excipients Council Foundation Emerging Research Award Funding. This work was supported, in part, by the Koch Institute Support(core) Grant P30-CA14051 from the National Cancer Institute. This work was supported, in entire or& in part, by the Gates Foundation (INV-061250). The conclusions and viewpoints revealed in this work are those of the author (s)alone and will not be credited to the Gates Foundation.
Under the grant conditions of the Gates Foundation, a Creative Commons Attribution 4.0 License has actually currently been designated to the Author Accepted Manuscript variation that may develop from this submission. Please note that works sent as a preprint have actually not gone through a peer evaluation procedure. Author info 19460505 Author notes These authors contributed similarly: Jinbi Tian, Khanh T. M. Tran. Authors and Affiliations 19460812 19460809 19460505 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Jinbi Tian, Khanh T. M. Tran, Brett H. Pogostin, Olivia Sheridan, Sevinj Mursalova, Amy H. Lee, Shuai Liu, Jaya Hamkins, Zane S. Dash, Dongsoo Yun, Robert S. Langer & Ana Jaklenec 19460532 Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Jinbi Tian & Mina Konaković Luković
19460511 19460532 19460505 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Daniel Antov 19460511 19460505 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 19460505 Alana L. Power 19460532 19460505 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 19460511 Robert S. Langer 19460511 19460532 19460798 19460505 Authors 19460819 Jinbi Tian 19460808 19460532 19460819 Khanh T. M. Tran Brett H. Pogostin 19460532 Olivia Sheridan 19460532 19460819 Sevinj Mursalova Amy H. Lee 19460808 19460532 Shuai Liu 19460808 19460532 Jaya Hamkins Daniel Antov Alana L. Power 19460808 19460819 Zane S. Dash 19460808 19460532 Dongsoo Yun 19460808 19460532 19460819 Mina Konaković Luković 19460532 Robert S. Langer 19460808 19460532 19460819 Ana Jaklenec 19460808 19460532
19460798 Contributions J.T. and K.T.M.T. developed the research study, developed and carried out the experiments, examined the information and composed the manuscript. B.H.P., O.S., S.M., A.H.L., S.L., J.H., D.A., A.L.P., D.Y. and Z.S.D. added to experiments, information collection and information analysis. M.K.L. supplied assistance on the algorithm advancement, application and information analysis. R.S.L. and A.J. developed and monitored the research study, protected financing, analyzed the information and modified the manuscript. All authors went over the outcomes, supplied crucial feedback and authorized the last manuscript. Corresponding authors 19460812 Correspondence to Robert S. Langer or Ana Jaklenec. 19460512
Ethics statements 19460504 Completing interests 19460812 From Fiscal Year 2020 to today, A.J. gets licensing charges (for patents on which she was an innovator)from, has financial investments in, consults( or was on Scientific Advisory Boards or Boards of Directors )for, lectured (and got a cost) or performs sponsored research study at MIT for which she was not spent for the following entities: The Estée Lauder Companies, Moderna Therapeutics, OmniPulse Biosciences, Particles for Humanity, SiO2 Materials Science and VitaKey. From Fiscal Year 2020 to today, R.S.L. gets licensing costs(for patents on which he was a creator)from, has financial investments in, consults(or was on Scientific Advisory Boards or Boards of Directors)for, lectured(and got a cost)or carries out sponsored research study at MIT for which he was not spent for the following entities: https://www.dropbox.com/scl/fo/9hrpxuzs72iwvmoqze7rx/AA_OoThWVjAex7X_LhwLRcw?rlkey=llza5qcutubtyx34uqrrfy141&st=zcgqc4qp&dl The staying authors state no completing interests. 19460511 19460512 Peer evaluation 19460504 Peer evaluation details 19460812 Nature Biotechnology thanks Yujia Cai, Yizhou Dong and the other, confidential, customer(s)for their contribution to the peer evaluation of this work. 19460511
Additional details 19460504 19460505 Publisher’s note Springer Nature stays neutral with regard to jurisdictional claims in released maps and institutional associations. 19460511
Supplementary info Rights and authorizations 19460504 19460505 Springer Nature or its licensor(e.g. a society or other partner)holds special rights to this short article under a publishing arrangement with the author(s)or other rightsholder(s); author self-archiving of the accepted manuscript variation of this post is exclusively governed by the regards to such publishing contract and appropriate law. 19460505 Reprints and approvals 19460507 19460511 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
19460798 Contributions J.T. and K.T.M.T. developed the research study, developed and carried out the experiments, examined the information and composed the manuscript. B.H.P., O.S., S.M., A.H.L., S.L., J.H., D.A., A.L.P., D.Y. and Z.S.D. added to experiments, information collection and information analysis. M.K.L. supplied assistance on the algorithm advancement, application and information analysis. R.S.L. and A.J. developed and monitored the research study, protected financing, analyzed the information and modified the manuscript. All authors went over the outcomes, supplied crucial feedback and authorized the last manuscript. Corresponding authors 19460812 Correspondence to Robert S. Langer or Ana Jaklenec. 19460512
Ethics statements 19460504 Completing interests 19460812 From Fiscal Year 2020 to today, A.J. gets licensing charges (for patents on which she was an innovator)from, has financial investments in, consults( or was on Scientific Advisory Boards or Boards of Directors )for, lectured (and got a cost) or performs sponsored research study at MIT for which she was not spent for the following entities: The Estée Lauder Companies, Moderna Therapeutics, OmniPulse Biosciences, Particles for Humanity, SiO2 Materials Science and VitaKey. From Fiscal Year 2020 to today, R.S.L. gets licensing costs(for patents on which he was a creator)from, has financial investments in, consults(or was on Scientific Advisory Boards or Boards of Directors)for, lectured(and got a cost)or carries out sponsored research study at MIT for which he was not spent for the following entities: https://www.dropbox.com/scl/fo/9hrpxuzs72iwvmoqze7rx/AA_OoThWVjAex7X_LhwLRcw?rlkey=llza5qcutubtyx34uqrrfy141&st=zcgqc4qp&dl The staying authors state no completing interests. 19460511 19460512 Peer evaluation 19460504 Peer evaluation details 19460812 Nature Biotechnology thanks Yujia Cai, Yizhou Dong and the other, confidential, customer(s)for their contribution to the peer evaluation of this work. 19460511
Additional details 19460504 19460505 Publisher’s note Springer Nature stays neutral with regard to jurisdictional claims in released maps and institutional associations. 19460511
Supplementary info Rights and authorizations 19460504 19460505 Springer Nature or its licensor(e.g. a society or other partner)holds special rights to this short article under a publishing arrangement with the author(s)or other rightsholder(s); author self-archiving of the accepted manuscript variation of this post is exclusively governed by the regards to such publishing contract and appropriate law. 19460505 Reprints and approvals 19460507 19460511 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
Additional details 19460504 19460505 Publisher’s note Springer Nature stays neutral with regard to jurisdictional claims in released maps and institutional associations. 19460511
Supplementary info Rights and authorizations 19460504 19460505 Springer Nature or its licensor(e.g. a society or other partner)holds special rights to this short article under a publishing arrangement with the author(s)or other rightsholder(s); author self-archiving of the accepted manuscript variation of this post is exclusively governed by the regards to such publishing contract and appropriate law. 19460505 Reprints and approvals 19460507 19460511 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
About this post 19460504 19460505 19460511 Mention this short article 19460812 Tian, J., Tran, K.T.M., Pogostin, B.H. 19460525 et al. 19460526 Sped up discovery of thermostable mRNA– lipid nanoparticle vaccines utilizing data-efficient AI. Nat Biotechnol 19460526 (2026). https://doi.org/10.1038/s41587-026-03331-w 19460511 Download citation 19460507 Gotten 19460819: 13 January 2026 19460808 Accepted : 19460808 02 September 2026 19460808 19460532 19460862 19460505 Released 19460819: 19460808 19460819 28 September 2026 19460864 19460511 19460862 19460505 Variation of record 19460819: 19460819 28 September 2026 19460808 19460532 19460862 19460505 DOI 19460819: https://doi.org/10.1038/s41587-026-03331-w 19460808 19460532 19460512 19460512 19460512 19460512
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